Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy.

ABSTRACT:

Background and aims

Patients who underwent carotid endarterectomy (CEA) still have a residual risk of 13% of developing a major adverse cardiovascular event (MACE) within 3 years. Inflammatory processes leading up to MACE are not fully understood. Therefore, we examined blood cell characteristics (BCCs), possibly reflecting inflammatory processes, in relation to MACE to identify BCCs that may contribute to an increased risk.

Methods

We analyzed 75 pretreatment BCCs from the Sapphire analyzer, and clinical data from the Athero-Express biobank in relation to MACE after CEA using Random Survival Forests, and a Generalized Additive Survival Model. To understand biological mechanisms, we related the identified variables to intraplaque hemorrhage (IPH).

Results

Of 783 patie

SUBMITTER: Overmars LM 

PROVIDER: S-EPMC10300576 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature