Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [¹⁸F]-PI-2620 tau-PET signal.

ABSTRACT: In recent years in vivo visualization of tau deposits has become possible with various PET radiotracers. The tau tracer [¹⁸F]PI-2620 proved high affinity both to 3-repeat/4-repeat tau in Alzheimer's disease as well as to 4-repeat tau in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). However, to be clinically relevant, biomarkers should not only correlate with pathological changes but also with disease stage and progression. Therefore, we aimed to investigate the correlation between topology of [¹⁸F]PI-2620 uptake and symptomatology in 4-repeat tauopathies. 72 patients with possible or probable 4-repeat tauopathy, i.e. 31 patients with PSP-Richardson's syndrome (PSP-RS), 30 with amyloid-negative CBS and 11 with PSP-non-RS/CBS, underwent [^18<

SUBMITTER: Schonecker S 

PROVIDER: S-EPMC10300609 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature