Evaluation of ATSDR's MRL and EPA's RfCs/RfDs: Similarities, Differences, and Rationales.

ABSTRACT:

Objectives

The Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA) derive minimal risk levels (MRLs) and reference concentrations and doses (RfCs and RfDs), respectively, for environmental contaminants to help identify potential health risks to exposed populations. MRLs, RfDs, and RfCs involve similar derivation methods, but the values sometimes differ for the same chemical. The objectives of this manuscript are to quantitatively assess similarities and differences between MRLs, RfCs, and RfDs, qualitatively describe how a number of factors can influence the development of the health guidance values (HGVs) and identify ongoing collaborations and opportunities for increased coordination of efforts.

Materials and methods

We co

SUBMITTER: Przybyla J 

PROVIDER: S-EPMC10300620 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature