Janus Kinase Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease. Several studies have reported outcomes of Janus kinase (JAK) inhibitors for treating AA, but limited evidence has emerged.

Objective

To evaluate the effectiveness and safety associated with JAK inhibitors for AA.

Data sources

MEDLINE, Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched from inception until August 2022.

Study selection

Only randomized clinical trials (RCTs) were included. Pairs of reviewers independently and in duplicate selected the studies.

Data extraction and synthesis

Hartung-Knapp-Sidik-Jonkman random-effects models were used for meta-analysis. Certainty of evidence was evaluated using the Grading of Recommendations,

SUBMITTER: Liu M 

PROVIDER: S-EPMC10300710 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature