Identification of Phase-Separation-Protein-Related Function Based on Gene Ontology by Using Machine Learning Methods.

ABSTRACT: Phase-separation proteins (PSPs) are a class of proteins that play a role in the process of liquid-liquid phase separation, which is a mechanism that mediates the formation of membranelle compartments in cells. Identifying phase separation proteins and their associated function could provide insights into cellular biology and the development of diseases, such as neurodegenerative diseases and cancer. Here, PSPs and non-PSPs that have been experimentally validated in earlier studies were gathered as positive and negative samples. Each protein's corresponding Gene Ontology (GO) terms were extracted and used to create a 24,907-dimensional binary vector. The purpose was to extract essential GO terms that can describe essential functions of PSPs and build efficient classifiers to identify PSPs

SUBMITTER: Ma Q 

PROVIDER: S-EPMC10300870 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature