Titanium-Mediated Reduction of Carboxamides to Amines with Borane-Ammonia.

ABSTRACT: In this study, the successful titanium tetrachloride-catalyzed reduction of aldehydes, ketones, carboxylic acids, and nitriles with borane-ammonia was extended to the reduction (deoxygenation) of a variety of aromatic and aliphatic pri-, sec- and tert-carboxamides, by changing the stoichiometry of the catalyst and reductant. The corresponding amines were isolated in good to excellent yields, following a simple acid-base workup.

SUBMITTER: Ramachandran PV 

PROVIDER: S-EPMC10301125 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature