Effects of Androgen Treatment on Growth in Patients with 5-α-Reductase Type 2 Deficiency.

ABSTRACT:

Background

Patients with 5-α-reductase type 2 deficiency (5αRD2) require androgen treatment for the growth of normal male external genitalia. Since limited research has been conducted on the effects of androgen treatment on height in individuals with 5αRD2, we investigated the effect of androgen treatment on bone age (BA) and the height status in children with 5αRD2.

Methods

Of the 19 participants who were followed up for an average of 10.6 years, 12 received androgen treatment. BA and height standard deviation scores (SDS) were compared between the treatment and non-treatment groups, as well as between the dihydrotestosterone (DHT) and testosterone enanthate (TE) treatment groups.

Results

Despite the above-average height of the 19 patients with 5αRD2, the height SDS

SUBMITTER: Lee HI 

PROVIDER: S-EPMC10301148 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature