Neutrophils in Cancer and Potential Therapeutic Strategies Using Neutrophil-Derived Exosomes.

ABSTRACT: Neutrophils are the most abundant immune cells and make up about 70% of white blood cells in human blood and play a critical role as the first line of defense in the innate immune response. They also help regulate the inflammatory environment to promote tissue repair. However, in cancer, neutrophils can be manipulated by tumors to either promote or hinder tumor growth depending on the cytokine pool. Studies have shown that tumor-bearing mice have increased levels of neutrophils in peripheral circulation and that neutrophil-derived exosomes can deliver various cargos, including lncRNA and miRNA, which contribute to tumor growth and degradation of extracellular matrix. Exosomes derived from immune cells generally possess anti-tumor activities and induce tumor-cell apoptosis by delivering cyt

SUBMITTER: Dutta A 

PROVIDER: S-EPMC10301170 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature