Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia.

ABSTRACT: Neuroinflammation plays a crucial role in the progression of Alzheimer's disease and other neurodegenerative disorders. Overactivated microglia cause neurotoxicity and prolong the inflammatory response in many neuropathologies. In this study, we have synthesised a series of isatin derivatives to evaluate their anti-neuroinflammatory potential using lipopolysaccharide activated microglia as a cell model. We explored four different substitutions of the isatin moiety by testing their anti-neuroinflammatory activity on BV2 microglia cells. Based on the low cytotoxicity and the activity in reducing the release of nitric oxide, pro-inflammatory interleukin 6 and tumour necrosis factor α by microglial cells, the N¹-alkylated compound 10 and the chlorinated 20 showe

SUBMITTER: Cenalmor A 

PROVIDER: S-EPMC10301261 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature