Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin.

ABSTRACT: The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M⁴⁺ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the coordination processes between MonH/SalH and ions of Ce⁴⁺. (1) Methods: Novel monensinate and salinomycinate cerium(IV)-based complexes were synthesized and structurally characterized by elemental analysis, a plethora of physicochemical methods, density functional theory, molecular dynamics, and biological assays. (2) Results: The formation of coordination species of a general composition [CeL₂(OH)₂] and [CeL(NO₃)₂(OH)], depending on reaction conditions, was proven both experime

SUBMITTER: Petkov N 

PROVIDER: S-EPMC10301318 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature