Dose-Dependent Inhibitory Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans-Candida albicans Cross-Kingdom Microorganisms.

ABSTRACT: Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. mutans and C. albicans in biofilms and in a rodent model of dental caries. The aim of this study was to investigate the dose-dependent effect of L. plantarum against S. mutans and C. albicans in a planktonic model that simulated a high-caries-risk clinical condition. Mono-, dual-, and multi-species models were utilized, with five doses of L. plantarum (ranging from 1.0 × 10⁴ to 1.0 × 10⁸ CFU/mL). Real-time PCR was used to assess the expression of the virulence genes of

SUBMITTER: Bao J 

PROVIDER: S-EPMC10301334 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature