Comparison of Attenuated and Virulent Strains of African Swine Fever Virus Genotype I and Serogroup 2.

ABSTRACT: African swine fever (ASF) is a contagious disease of pigs caused by the ASF virus (ASFV). The main problem in the field of ASF control is the lack of vaccines. Attempts to obtain vaccines by attenuating the ASFV on cultured cell lines led to the production of attenuated viruses, some of which provided protection against infection with a homologous virus. Here we report on the biological and genomic features of the attenuated Congo-a (KK262) virus compared to its virulent homologue Congo-v (K49). Our results showed differences in in vivo replication and virulence of Congo-a. However, the attenuation of the K49 virus did not affect its ability to replicate in vitro in the primary culture of pig macrophages. Complete genome sequencing of the attenuated KK262 strain revealed an 8,8 kb deletion

SUBMITTER: Kholod N 

PROVIDER: S-EPMC10301422 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature