Anatomical Targeting of Anticancer Drugs to Solid Tumors Using Specific Administration Routes: Review.

ABSTRACT: Despite remarkable recent progress in developing anti-cancer agents, outcomes of patients with solid tumors remain unsatisfactory. In general, anti-cancer drugs are systemically administered through peripheral veins and delivered throughout the body. The major problem with systemic chemotherapy is insufficient uptake of intravenous (IV) drugs by targeted tumor tissue. Although dose escalation and treatment intensification have been attempted in order to increase regional concentrations of anti-tumor drugs, these approaches have produced only marginal benefits in terms of patient outcomes, while often damaging healthy organs. To overcome this problem, local administration of anti-cancer agents can yield markedly higher drug concentrations in tumor tissue with less systemic toxicity. This st

SUBMITTER: Saito A 

PROVIDER: S-EPMC10301590 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature