Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery.

ABSTRACT: Therapeutic proteins garnered significant attention in the field of disease treatment. In comparison to small molecule drugs, protein therapies offer distinct advantages, including high potency, specificity, low toxicity, and reduced carcinogenicity, even at minimal concentrations. However, the full potential of protein therapy is limited by inherent challenges such as large molecular size, delicate tertiary structure, and poor membrane penetration, resulting in inefficient intracellular delivery into target cells. To address these challenges and enhance the clinical applications of protein therapies, various protein-loaded nanocarriers with tailored modifications were developed, including liposomes, exosomes, polymeric nanoparticles, and nanomotors. Despite these advancements, many of the

SUBMITTER: He X 

PROVIDER: S-EPMC10301687 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature