Antibody Therapeutics as Interfering Agents in Flow Cytometry Crossmatch for Organ Transplantation.

ABSTRACT: Donor-recipient matching is a highly individualized and complex component of solid organ transplantation. Flowcytometry crossmatching (FC-XM) is an integral step in the matching process that is used to detect pre-formed deleterious anti-donor immunoglobulin. Despite high sensitivity in detecting cell-bound immunoglobulin, FC-XM is not able to determine the source or function of immunoglobulins detected. Monoclonal antibody therapeutic agents used in a clinic can interfere with the interpretation of FC-XM. We combined data from the prospectively maintained Antibody Society database and Human Protein Atlas with a comprehensive literature review of PubMed to summarize known FC-XM-interfering antibody therapeutics and identify potential interferers. We identified eight unique FC-XM-interfering

SUBMITTER: Kueht ML 

PROVIDER: S-EPMC10301800 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature