Determination of Mucoadhesion of Polyvinyl Alcohol Films to Human Intestinal Tissue.

ABSTRACT: The absorption of drugs with narrow absorption windows in the upper small intestine can be improved with a mucoadhesive drug delivery system such as enteric films. To predict the mucoadhesive behaviour in vivo, suitable in vitro or ex vivo methods can be performed. In this study, the influence of tissue storage and sampling site on the mucoadhesion of polyvinyl alcohol film to human small intestinal mucosa was investigated. Tissue from twelve human subjects was used to determine adhesion using a tensile strength method. Thawing of tissue frozen at -20 °C resulted in a significantly higher work of adhesion (p = 0.0005) when a low contact force was applied for one minute, whereas the maximum detachment force was not affected. When the contact force and time were increased, no differen

SUBMITTER: Muller L 

PROVIDER: S-EPMC10301857 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature