Vitamin D Supplementation Impacts Calcium and Phosphorus Metabolism in Piglets Fed a Diet Contaminated with Deoxynivalenol and Challenged with Lipopolysaccharides.

ABSTRACT: Using alternative feed ingredients in pig diets can lead to deoxynivalenol (DON) contamination. DON has been shown to induce anorexia, inflammation, and-more recently-alterations in the vitamin D, calcium, and phosphorus metabolisms. Adding vitamin D supplementation in the form of vitamin D₃ and 25-OH-D₃ to the feed could modify the effects of DON in piglets. In this study, vitamin D₃ or 25-OH-D₃ supplementation was used in a control or DON-contaminated treatment. A repetitive exposure over 21 days to DON in the piglets led to disruptions in the vitamin D, calcium, and phosphorus metabolisms, resulting in a decreased growth performance, increased bone mineralization, and the downregulation of genes related to calcium and to phosphorus intestinal

SUBMITTER: Sauve B 

PROVIDER: S-EPMC10302099 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature