Newly Designed Cysteine-Based Self-Assembling Prodrugs for Sepsis Treatment.

ABSTRACT: Reactive oxygen species (ROS) are essential signaling molecules that maintain intracellular redox balance; however, the overproduction of ROS often causes dysfunction in redox homeostasis and induces serious diseases. Antioxidants are crucial candidates for reducing overproduced ROS; however, most antioxidants are less effective than anticipated. Therefore, we designed new polymer-based antioxidants based on the natural amino acid, cysteine (Cys). Amphiphilic block copolymers, composed of a hydrophilic poly(ethylene glycol) (PEG) segment and a hydrophobic poly(cysteine) (PCys) segment, were synthesized. In the PCys segment, the free thiol groups in the side chain were protected by thioester moiety. The obtained block copolymers formed self-assembling nanoparticles (Nano^Cys(Bu))

SUBMITTER: Koda Y 

PROVIDER: S-EPMC10302134 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature