From Soma to Synapse: Imaging Age-Related Rod Photoreceptor Changes in the Mouse with Visible Light OCT.

ABSTRACT:

Purpose

Although the outer nuclear layer (ONL) and outer plexiform layer (OPL) each exhibit a complex internal organization, near-infrared OCT depicts both as monolithic bands. Here, using visible light OCT in the C57BL/6J mouse retina, sublaminar age-related changes in photoreceptor features were imaged and interpreted. These features were (1) oscillations in reflectivity, or striations, in the ONL and (2) a moderately reflective subband in the OPL.

Design

Cross-sectional study.

Participants

Pigmented mice (C57BL/6J, n = 14).

Methods

A 1.0-μm axial resolution visible light spectral/Fourier domain OCT system was used for in vivo retinal imaging. Light and electron microscopy were performed ex vivo. Linear mixed effects models or regression were employed for sta

SUBMITTER: Chauhan P 

PROVIDER: S-EPMC10302163 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature