Whole Genome Sequencing of Avian Pathogenic Escherichia coli Causing Bacterial Chondronecrosis and Osteomyelitis in Australian Poultry.

ABSTRACT: Bacterial chondronecrosis with osteomyelitis (BCO) impacts animal welfare and productivity in the poultry industry worldwide, yet it has an understudied pathogenesis. While Avian Pathogenic Escherichia coli (APEC) are known to be one of the main causes, there is a lack of whole genome sequence data, with only a few BCO-associated APEC (APEC_BCO) genomes available in public databases. In this study, we conducted an analysis of 205 APEC_BCO genome sequences to generate new baseline phylogenomic knowledge regarding the diversity of E. coli sequence types and the presence of virulence associated genes (VAGs). Our findings revealed the following: (i) APEC_BCO are phylogenetically and genotypically similar to APEC that cause colibacillosis (APEC_co

SUBMITTER: Cummins ML 

PROVIDER: S-EPMC10302171 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature