Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial.

ABSTRACT:

Objective

To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence of major cardiovascular events.

Design

Randomised, double blind, placebo controlled trial of monthly vitamin D (the D-Health Trial). Computer generated permuted block randomisation was used to allocate treatments.

Setting

Australia from 2014 to 2020.

Participants

21 315 participants aged 60-84 years at enrolment. Exclusion criteria were self-reported hypercalcaemia, hyperparathyroidism, kidney stones, osteomalacia, sarcoidosis, taking >500 IU/day supplemental vitamin D, or unable to give consent because of language or cognitive impairment.

Intervention

60 000 IU/month vitamin D₃ (n=10 662) or placebo (n=10 653) taken orally for up t

SUBMITTER: Thompson B 

PROVIDER: S-EPMC10302209 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature