Menopausal hormone therapy and dementia: nationwide, nested case-control study.

ABSTRACT:

Objectives

To assess the association between use of menopausal hormone therapy and development of dementia according to type of hormone treatment, duration of use, and age at usage.

Design

Nationwide, nested case-control study.

Setting

Denmark through national registries.

Participants

5589 incident cases of dementia and 55 890 age matched controls were identified between 2000 and 2018 from a population of all Danish women aged 50-60 years in 2000 with no history of dementia or contraindications for use of menopausal hormone therapy.

Main outcome measures

Adjusted hazard ratios with 95% confidence intervals for all cause dementia defined by a first time diagnosis or first time use of dementia specific medication.

Results

Compared with people who ha

SUBMITTER: Pourhadi N 

PROVIDER: S-EPMC10302215 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature