The effect of mifepristone pretreatment on bleeding and pain during medical management of early pregnancy loss.

ABSTRACT:

Objectives

To compare participant-reported bleeding and pain with two medication regimens for early pregnancy loss (EPL).

Study design

We performed a secondary analysis of a randomized trial in which participants took either mifepristone 200 mg orally followed by misoprostol 800 mcg vaginally 24 hours later or misoprostol alone for medical management of EPL. Participants reported bleeding and pain (Numeric Pain Rating Scale, NPRS, 0-10) with daily paper diaries and at study visits on trial days 3, 8, and 30. We used, Fisher's exact, Pearson chi-square, Wilcoxon rank sum, and Student's t-tests to compare onset, duration, and severity of bleeding and pain symptoms between trial arms after misoprostol administration.

Results

Among 291 participants who submitted diary dat

SUBMITTER: Roe AH 

PROVIDER: S-EPMC10302372 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature