Large-Scale Modeling of Sparse Protein Kinase Activity Data.

ABSTRACT: Protein kinases are a protein family that plays an important role in several complex diseases such as cancer and cardiovascular and immunological diseases. Protein kinases have conserved ATP binding sites, which when targeted can lead to similar activities of inhibitors against different kinases. This can be exploited to create multitarget drugs. On the other hand, selectivity (lack of similar activities) is desirable in order to avoid toxicity issues. There is a vast amount of protein kinase activity data in the public domain, which can be used in many different ways. Multitask machine learning models are expected to excel for these kinds of data sets because they can learn from implicit correlations between tasks (in this case activities against a variety of kinases). However, multitask

SUBMITTER: Luukkonen S 

PROVIDER: S-EPMC10302492 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature