Differential regulation of Shigella Spa47 ATPase activity by a native C-terminal product of Spa33.

ABSTRACT: Shigella is a Gram-negative bacterial pathogen that relies on a single type three secretion system (T3SS) as its primary virulence factor. The T3SS includes a highly conserved needle-like apparatus that directly injects bacterial effector proteins into host cells, subverting host cell function, initiating infection, and circumventing resulting host immune responses. Recent findings have located the T3SS ATPase Spa47 to the base of the Shigella T3SS apparatus and have correlated its catalytic function to apparatus formation, protein effector secretion, and overall pathogen virulence. This critical correlation makes Spa47 ATPase activity regulation a likely point of native control over Shigella virulence and a high interest target for non-antibiotic- based therapeutics.

SUBMITTER: Case HB 

PROVIDER: S-EPMC10302723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature