Mesenchymal Stem Cell Membrane-Coated TPCS_2a-Loaded Nanoparticles for Breast Cancer Photodynamic Therapy.

ABSTRACT: Despite substantial improvements in breast cancer (BC) treatment there is still an urgent need to find alternative treatment options to improve the outcomes for patients with advanced-stage disease. Photodynamic therapy (PDT) is gaining a lot of attention as a BC therapeutic option because of its selectivity and low off-target effects. However, the hydrophobicity of photosensitizers (PSs) impairs their solubility and limits the circulation in the bloodstream, thus representing a major challenge. The use of polymeric nanoparticles (NPs) to encapsulate the PS may represent a valuable strategy to overcome these issues. Herein, we developed a novel biomimetic PDT nanoplatform (NPs) based on a polymeric core of poly(lactic-co-glycolic)acid (PLGA) loaded with the PS meso-tetraphenylchlorin disul

SUBMITTER: Avancini G 

PROVIDER: S-EPMC10302938 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature