Phosphorylated STAT3 as a potential diagnostic and predictive biomarker in ALK^- ALCL vs. CD30^high PTCL, NOS.

ABSTRACT:

Aims

The differential diagnosis between ALK-negative anaplastic large cell lymphoma (ALK^- ALCL) and peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with high expression of CD30 (CD30^high) are essential. However, no reliable biomarker is available in daily practice except CD30. STAT3 is characteristically activated in ALCL. We aimed to investigate whether the status of STAT3 phosphorylation could help the differential diagnosis.

Methods

The status of phosphorylation of STAT3 was examined using two antibodies against pSTAT3-Y705 and pSTAT3-S727 by immunohistochemistry in ALK⁺ ALCL (n=33), ALK^- ALCL (n=22) and PTCL, NOS (n=34). Ten PTCL, NOS with diffuse CD30 expression were defined as CD30^high PTCL, NOS. Fl

SUBMITTER: Xiang C 

PROVIDER: S-EPMC10303105 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature