Impaired Cardiomyocyte Maturation Leading to DCM: A Case Report and Literature Review.

ABSTRACT: Background: The maturation of cardiomyocytes is a rapidly evolving area of research within the field of cardiovascular medicine. Understanding the molecular mechanisms underlying cardiomyocyte maturation is essential to advancing our knowledge of the underlying causes of cardiovascular disease. Impaired maturation can lead to the development of cardiomyopathy, particularly dilated cardiomyopathy (DCM). Recent studies have confirmed the involvement of the ACTN2 and RYR2 genes in the maturation process, facilitating the functional maturation of the sarcomere and calcium handling. Defective sarcomere and electrophysiological maturation have been linked to severe forms of cardiomyopathy. This report presents a rare case of DCM with myocardial non-compaction, probably resul

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10303204 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature