Phenotypic Changes in T and NK Cells Induced by Sputnik V Vaccination.

ABSTRACT: A highly effective humoral immune response induced by the Sputnik V vaccine was demonstrated in independent studies, as well as in large-scale post-vaccination follow-up studies. However, the shifts in the cell-mediated immunity induced by Sputnik V vaccination are still under investigation. This study was aimed at estimating the impact of Sputnik V on activating and inhibitory receptors, activation and proliferative senescence markers in NK and T lymphocytes. The effects of Sputnik V were evaluated by the comparison of PBMC samples prior to vaccination, and then three days and three weeks following the second (boost) dose. The prime-boost format of Sputnik V vaccination induced a contraction in the T cell fraction of senescent CD57⁺ cells and a decrease in HLA-DR-expressing T c

SUBMITTER: Boyko AA 

PROVIDER: S-EPMC10303265 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature