Dataset Information

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD³).

ABSTRACT: In an era of unparalleled technical advancement, the pharmaceutical industry is struggling to transform data into increased research and development efficiency, and, as a corollary, new drugs for patients. Here, we briefly review some of the commonly discussed issues around this counterintuitive innovation crisis. Looking at both industry- and science-related factors, we posit that traditional preclinical research is front-loading the development pipeline with data and drug candidates that are unlikely to succeed in patients. Applying a first principles analysis, we highlight the critical culprits and provide suggestions as to how these issues can be rectified through the pursuit of a Human Data-driven Discovery (HD³) paradigm. Consistent with other examples of disruptive innovation, we propose that new levels of success are not dependent on new inventions, but rather on the strategic integration of existing data and technology assets. In support of these suggestions, we highlight the power of HD³, through recently published proof-of-concept applications in the areas of drug safety analysis and prediction, drug repositioning, the rational design of combination therapies and the global response to the COVID-19 pandemic. We conclude that innovators must play a key role in expediting the path to a largely human-focused, systems-based approach to drug discovery and research.

SUBMITTER: Jackson DB

PROVIDER: S-EPMC10303279 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Rewiring Drug Research and Development through Human Data-Driven Discovery (HD<sup>3</sup>).

Jackson David B DB Racz Rebecca R Kim Sarah S Brock Stephan S Burkhart Keith K

Pharmaceutics 20230607 6

In an era of unparalleled technical advancement, the pharmaceutical industry is struggling to transform data into increased research and development efficiency, and, as a corollary, new drugs for patients. Here, we briefly review some of the commonly discussed issues around this counterintuitive innovation crisis. Looking at both industry- and science-related factors, we posit that traditional preclinical research is front-loading the development pipeline with data and drug candidates that are u ...[more]

PMID: 37376121

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Dataset Information

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD³).

Publications

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD<sup>3</sup>).

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Dataset Information

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD3).

Publications

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD<sup>3</sup>).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD³).