A bidirectional Mendelian randomization study about the role of morning plasma cortisol in attention deficit hyperactivity disorder.

ABSTRACT:

Context

Cortisol, a hormone regulated by the hypothalamic-pituitary-adrenal (HPA) axis, has been linked to attention deficit hyperactivity disorder (ADHD). The nature of the relationship between cortisol and ADHD, and whether it is causal or explained by reverse causality, remains a matter of debate.

Objective

This study aims to evaluate the bidirectional causal relationship between morning plasma cortisol levels and ADHD.

Methods

This study used a bidirectional 2-sample Mendelian randomization (MR) design to analyze the association between morning plasma cortisol levels and ADHD using genetic information from the authoritative Psychiatric Genomics Collaboration (PGC) database (n = 55,347) and the ADHD Working Group of the CORtisol NETwork (CORNET) Consortium (

SUBMITTER: Jue H 

PROVIDER: S-EPMC10303788 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature