The effects of metformin on anti-Mullerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis.

ABSTRACT:

Objective

To analyze whether metformin treatment in patients with polycystic ovary syndrome (PCOS) results in a decrease of anti-Müllerian hormone (AMH) levels, we reviewed and analyzed PCOS studies which evaluated serum AMH levels before and after metformin treatment.

Methods

This is a systematic review and meta-analysis of self-controlled clinical trials. Databases including PubMed, Embase, and Web of Science library were searched to identify eligible studies published before February 2023. Random-effects models were applied to assess standardized mean differences (SMDs) with 95% confidence intervals (95% CI).

Results

The electronic-based search retrieved 167 articles of which 14 studies (12 publications) involving 257 women with PCOS were included. In general, AMH

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10303859 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature