PATH-SURVEYOR: pathway level survival enquiry for immuno-oncology and drug repurposing.

ABSTRACT: Pathway-level survival analysis offers the opportunity to examine molecular pathways and immune signatures that influence patient outcomes. However, available survival analysis algorithms are limited in pathway-level function and lack a streamlined analytical process. Here we present a comprehensive pathway-level survival analysis suite, PATH-SURVEYOR, which includes a Shiny user interface with extensive features for systematic exploration of pathways and covariates in a Cox proportional-hazard model. Moreover, our framework offers an integrative strategy for performing Hazard Ratio ranked Gene Set Enrichment Analysis and pathway clustering. As an example, we applied our tool in a combined cohort of melanoma patients treated with checkpoint inhibition (ICI) and identified several immune po

SUBMITTER: Obermayer AN 

PROVIDER: S-EPMC10303868 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature