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Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay.


ABSTRACT: Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.

SUBMITTER: Vazquez C 

PROVIDER: S-EPMC10304136 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay.

Vazquez Cynthia C   Alcantara Luiz Carlos Junior LCJ   Fonseca Vagner V   Lima Mauricio M   Xavier Joilson J   Adelino Talita T   Fritsch Hegger H   Castro Emerson E   de Oliveira Carla C   Schuab Gabriel G   Lima Alex Ranieri Jerônimo ARJ   Villalba Shirley S   Gomez de la Fuente Andrea A   Rojas Analia A   Cantero Cesar C   Fleitas Fatima F   Aquino Carolina C   Ojeda Andrea A   Sequera Guillermo G   Torales Juan J   Barrios Julio J   Elias Maria Carolina MC   Iani Felipe C M FCM   Ortega Maria Jose MJ   Gamarra Maria Liz ML   Montoya Romeo R   Rodrigues Evandra Strazza ES   Kashima Simone S   Sampaio Sandra Coccuzzo SC   Coluchi Norma N   Leite Juliana J   Gresh Lionel L   Franco Leticia L   Lourenço José J   Rico Jairo Mendez JM   Bispo de Filippis Ana Maria AM   Giovanetti Marta M  

Viruses 20230530 6


Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circ  ...[more]

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