Bivalent mRNA vaccine effectiveness against SARS-CoV-2 variants of concern.

ABSTRACT:

Background

Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) virus and its variants. Mutations in SARS-CoV-2's spike protein can easily alter viral transmission and vaccination effectiveness.

Methods

In this study, we designed full-length spike mRNAs for WT, Alpha, Delta, and BA.5 variants and integrated each into monovalent or bivalent mRNA-lipid nanoparticle vaccines. A pseudovirus neutralization assay was conducted on immunized mouse sera in order to examine the neutralizing potential of each vaccine.

Results

Monovalent mRNA vaccines were only effective against the same type of virus. Interestingly, monovalent

SUBMITTER: Kumari M 

PROVIDER: S-EPMC10304269 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature