CoVigator-A Knowledge Base for Navigating SARS-CoV-2 Genomic Variants.

ABSTRACT:

Background

The outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in the global COVID-19 pandemic. The urgency for an effective SARS-CoV-2 vaccine has led to the development of the first series of vaccines at unprecedented speed. The discovery of SARS-CoV-2 spike-glycoprotein mutants, however, and consequentially the potential to escape vaccine-induced protection and increased infectivity, demonstrates the persisting importance of monitoring SARS-CoV-2 mutations to enable early detection and tracking of genomic variants of concern.

Results

We developed the CoVigator tool with three components: (1) a knowledge base that collects new SARS-CoV-2 genomic data, processes it and stores its results; (2) a comprehensive variant calling pipeline; (3

SUBMITTER: Bukur T 

PROVIDER: S-EPMC10304279 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature