Gegen Qinlian Decoction treatment of asymptomatic hyperuricemia by targeting circadian immune function.

ABSTRACT:

Background

The Gegen Qinlian Decoction (GGQLD) is a renowned traditional Chinese medicinal formula that has been used for centuries to effectively treat asymptomatic Hyperuricemia (HUA). This study aims to investigate the underlying mechanism of GGQLD's therapeutic effects on HUA.

Methods

The study enrolled a total of 25 healthy participants and 32 middle-aged and elderly individuals with asymptomatic HUA. All asymptomatic HUA participants were treated with GGQLD. Venous blood samples were collected from all participants to isolate peripheral blood mononuclear cells (PBMCs), which were then analyzed for biological profiles using flow cytometry. Network pharmacology analysis was utilized to identify the potential pathways involved in the therapeutic effects of GGQLD. Transcri

SUBMITTER: Wang X 

PROVIDER: S-EPMC10304353 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature