α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

ABSTRACT:

Background

Adherens junctions (AJs) facilitate cell-cell contact and contribute to cellular communication as well as signaling under physiological and pathological conditions. Aberrant expression of AJ proteins is frequently observed in human cancers; however, how these factors contribute to tumorigenesis is poorly understood. In addition, for some factors such as α-catenin contradicting data has been described. In this study we aim to decipher how the AJ constituent α-catenin contributes to liver cancer formation.

Methods

TCGA data was used to detect transcript changes in 23 human tumor types. For the detection of proteins, liver cancer tissue microarrays were analyzed by immunohistochemistry. Liver cancer cell lines (HLF, Hep3B, HepG2) were used for viability, proliferatio

SUBMITTER: Tang Y 

PROVIDER: S-EPMC10304383 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature