The Chemometric Evaluation of the Factors Influencing Cloud Point Extraction for Fluoroquinolones.

ABSTRACT: This study aimed to analyze the factors that impact the cloud point extraction of ciprofloxacin, levofloxacin, and moxifloxacin. The following independent variables were analyzed: Triton X-114 concentration, NaCl concentration, pH, and incubation temperature. The dependent variable studied was recovery. A central composite design model was used. The applied quantitation method was HPLC. The method was validated for linearity, precision, and accuracy. The results underwent ANOVA^® analysis. The polynomial equations were generated for each analyte. The response surface methodology graphs visualized them. The analysis showed that the factor most affecting the recovery of levofloxacin is the concentration of Triton X-114, while the recovery of ciprofloxacin and moxifloxacin is most a

SUBMITTER: Michalowska A 

PROVIDER: S-EPMC10304411 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature