Identification and immunological characterization of cuproptosis-related molecular clusters in ulcerative colitis.

ABSTRACT:

Background

Ulcerative colitis is one of the two main forms of inflammatory bowel disease. Cuproptosis is reported to be a novel mode of cell death.

Methods

We examined clusters of cuproptosis related genes and immune cell infiltration molecules in 86 ulcerative colitis samples from the GSE179285 dataset. We identified the differentially expressed genes according to the clustering method, and the performance of the SVM model, the random forest model, the generalized linear model, and the limit gradient enhancement model were compared, and then the optimal machine model was selected. To assess the accuracy of the learning predictions, the nomogram and the calibration curve and decision curve analyses showed that the subtypes of ulcerative colitis have been accurately predicted

SUBMITTER: Pu Y 

PROVIDER: S-EPMC10304604 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature