Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models.

ABSTRACT: Acute lung injury (ALI) is one of the most common clinical emergencies with limited effective pharmaceutical treatment in the clinic, especially when it progresses to acute respiratory distress syndrome (ARDS). Currently, mesenchymal stem cells (MSCs) exhibit specific superiority for ALI/ARDS treatment. However, stem cells from different sources may result in controversial effects on similar disease conditions. This study aimed to determine the effects of human amnion-derived mesenchymal stem cells (hAMSCs) on two different ALI mice model. The administered hAMSCs effectively accumulated in the lung tissues in all hAMSC-treated groups. Compared with the model and 1% human serum albumin (HSA) groups, high-dose hAMSCs (1.0 × 10⁶ cells) group significantly alleviated alveolar-capill

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10304826 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature