Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach.

ABSTRACT: Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cyclotrons, constitute a practical and reliable alternative. In this study, we discuss the production, purification, and radiolabeling of antibodies and nanobodies using copper-64 obtained from both solid and liquid targets. Copper-64 production from solid targets was performed on a TR-19 cyclotron with an energy of 11.7 MeV, while liquid target production was obtained by bombarding a

SUBMITTER: Hrynchak I 

PROVIDER: S-EPMC10304849 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature