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Three New Benzophenone Derivatives from Selaginella tamariscina.


ABSTRACT: Six compounds including three new benzophenones, selagibenzophenones D-F (1-3), two known selaginellins (4-5) and one known flavonoid (6), were isolated from Selaginella tamariscina. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound 1 represents the second example of diarylbenzophenone from natural sources. Compound 2 possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound 2 showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds 4 and 5 showed moderate inhibitory activity to HepG2 cells. Compounds 2 and 5 also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production.

SUBMITTER: Long J 

PROVIDER: S-EPMC10304954 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i>.

Long Jiayin J   Mao Qingqing Q   Peng Yujie Y   Liu Lei L   Hong Yin Y   Xiang Honglin H   Ma Ming M   Zou Hui H   Kuang Junwei J  

Molecules (Basel, Switzerland) 20230606 12


Six compounds including three new benzophenones, selagibenzophenones D-F (<b>1</b>-<b>3</b>), two known selaginellins (<b>4</b>-<b>5</b>) and one known flavonoid (<b>6</b>), were isolated from <i>Selaginella tamariscina</i>. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound <b>1</b> represents the second example of diarylbenzophenone from natural sources. Compound <b>2</b> possesses an unusual biphenyl-bisbenzophenone structure. Their cytot  ...[more]

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