Autonomic dysregulation, cognition and fatigue in people with depression and in active and healthy controls: observational cohort study.

ABSTRACT:

Background

Autonomic nervous system (ANS) dysregulation might be relevant to the pathophysiology of fatigue and cognitive impairment in depression and perhaps should be considered when making prescribing decisions.

Aims

To determine the relationship of self-reported ANS symptoms with fatigue, cognition and prescribed medication in people with a diagnosis of depression, in comparators without depression but with other mental health, neurodevelopmental or neurodegenerative disorders (active controls) and in healthy controls.

Method

Cross-sectional analysis of an opportunistic sample from England. Self-reported data were collected on demographics, diagnosis, medication, ANS symptoms (Composite Autonomic Symptom Scale-31, COMPASS-31) and fatigue (Visual Analogue Scale for

SUBMITTER: Costa T 

PROVIDER: S-EPMC10305035 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature