Novel Therapeutic Approaches in Inherited Neuropathies: A Systematic Review.

ABSTRACT: The management of inherited neuropathies relies mostly on the treatment of symptoms. In recent years, a better understanding of the pathogenic mechanisms that underlie neuropathies has allowed for the development of disease-modifying therapies. Here, we systematically review the therapies that have emerged in this field over the last five years. An updated list of diseases with peripheral neuropathy as a clinical feature was created based on panels of genes used clinically to diagnose inherited neuropathy. This list was extended by an analysis of published data by the authors and verified by two experts. A comprehensive search for studies of human patients suffering from one of the diseases in our list yielded 28 studies that assessed neuropathy as a primary or secondary outcome. Although

SUBMITTER: Hustinx M 

PROVIDER: S-EPMC10305260 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature