Moisture Behavior of Pharmaceutical Powder during the Tableting Process.

ABSTRACT: The moisture content of pharmaceutical powder is a key parameter contributing to tablet sticking during the tableting process. This study investigates powder moisture behavior during the compaction phase of the tableting process. Finite element analysis software COMSOL Multiphysics^® 5.6 was used to simulate the compaction microcrystalline cellulose (VIVAPUR PH101) powder and predict temperature and moisture content distributions, as well as their evolution over time, during a single compaction. To validate the simulation, a near-infrared sensor and a thermal infrared camera were used to measure tablet surface temperature and surface moisture, respectively, just after ejection. The partial least squares regression (PLS) method was used to predict the surface moisture content of t

SUBMITTER: Koumbogle K 

PROVIDER: S-EPMC10305356 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature