Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family.

ABSTRACT:

Objective

Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified. Members of the solute carrier (SLC) 22 family have substrates in common with the known TH transporters of the organic anion-transporting peptide family. Therefore, we screened the SLC22 family for TH transporters.

Methods

Uptake of 1 nM of iodothyronines or sulfated iodothyronines in COS1 cells expressing SLC22 proteins was performed.

Results

We first tested 25 mouse (m) SLC22 proteins for TH uptake and found that the majority of the organic anion transporter (OAT) clade were capable of 3,3',5-triiodothyronine and/or thyroxine (T4) transport. Based on phylogenetic tre

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10305468 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature