Food-induced cortisol secretion is comparable in lean and obese male subjects.

ABSTRACT:

Objective

Hypercortisolism is a risk factor for obesity. Cortisol increases in response to food intake in lean subjects. In obese subjects, disturbances of the food-induced cortisol peak were reported, but data from sufficiently powered and well-controlled trials are lacking. Understanding the cortisol response to food is essential as amplified or recurrent cortisol surges could lead to hypercortisolism and contribute to obesity. Therefore, we investigate the cortisol response to food in lean and obese subjects.

Design

This is a non-randomized, open-label study.

Methods

We assessed serum cortisol values after a high-calorie meal in lean and obese male subjects. Cortisol levels were frequently assessed before and for 3 h after food intake.

Results

A total of 36

SUBMITTER: Arroyo Tardio P 

PROVIDER: S-EPMC10305480 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature