Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis.

ABSTRACT: Tuberculosis (TB) is the deadliest disease caused by a bacterial agent. Glucocorticoids (GCs) have a typical anti-inflammatory effect, but recently it has been shown that they can present proinflammatory activity, mainly by increasing molecules from innate immunity. In the current study, we evaluated the effect of low doses of dexamethasone on Mycobacterium tuberculosis in vivo and in vitro. We used an established mice model of progressing tuberculosis (TB) in the in vivo studies. Intratracheal or intranasal dexamethasone therapy administered with conventional antibiotics in the late stage of the disease decreased the lung bacilli load and lung pneumonia, and increased the survival of the animals. Finally, the treatment decreased the inflammatory response in the SNC and, therefore,

SUBMITTER: Lara-Espinosa JV 

PROVIDER: S-EPMC10305529 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature