Predicting antipsychotic-induced weight gain in first episode psychosis - A field-wide systematic review and meta-analysis of non-genetic prognostic factors.

ABSTRACT:

Background

Whether non-genetic prognostic factors significantly influence the variable prognosis of antipsychotic-induced weight gain (AIWG) has not yet been systematically explored.

Methods

Searches for both randomized and non-randomized studies were undertaken using four electronic databases, two trial registers, and via supplemental searching methods. Unadjusted and adjusted estimates were extracted. Meta-analyses were undertaken using a random-effects generic inverse model. Risk of bias and quality assessments were undertaken using Quality in Prognosis Studies (QUIPS) and Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively.

Results

Seventy-two prognostic factors were assessed across 27 studies involving 4426 participants. Only a

SUBMITTER: Fitzgerald I 

PROVIDER: S-EPMC10305761 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature